ZIA CP010126-10368 (ZIA) | |||
---|---|---|---|
Title | Breast Cancer Density | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Brinton | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $661,953 | Project Dates | 05/01/2006 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Surveillance |
|||
Abstract | |||
Special funding for this project has been obtained from the sale of breast cancer stamps. The primary aims relate to understanding biologic correlates of dense breasts--a major risk factor for breast cancer. Special emphasis is being placed on assessing tissue markers. The study, being conducted at the University of Vermont Breast Cancer Screening Consortium Center, involves recruitment of women undergoing breast biopies, some of whom are subsequently referred for breast resections. Biologic samples from this latter group of women are being used for biomarker discovery, which then will be tested among the smaller materials derived the larger group of women undergoing breast biopsies. It is anticipated that initial interest will focus on markers that may be important in allowing for development of stromal components in the breast. This will include TGF-beta, as well as other markers that may be influenced by a variety of hormonal factors. |